Scentsational Ion Channels
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چکیده
منابع مشابه
Scentsational Ion Channels
Department of Biological Sciences tion and action potential generation. In frogs, it was Columbia University shown that out of a panel of some 65 odors about half New York, New York 10027 generated a biochemically significant increase in cAMP (Sklar et al., 1986). This was initially taken as evidence that a second pathway might exist for these odors. However , a simple but elegant experiment by...
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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
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Ion channels catalyze the transmembrane movement of small inorganic ions across biological membranes. They do so by forming continuous, hydrophilic pores through which ions can cross the barrier imposed by the lipid bilayer hydrophobic core. Ion channels serve many functions: they underlie the changes in membrane potential that control many cell functions, including the propagated electrical si...
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Seventeen derivatives of α- and β-cyclodextrins were prepared from the cyclodextrin per-6-azide by "click" cyclization with terminal alkynes. Sixteen of these "half-channel" compounds showed significant activity as ion channels in planar bilayer members as assessed by the voltage-clamp technique. Activity ranged from persistent square-top openings to highly erratic conductance; mixed behaviours...
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ژورنال
عنوان ژورنال: Neuron
سال: 1996
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80212-3